Friedrich Miescher Institute for Biomedical Research (FMI)

The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute with a twofold mission – understanding the molecular mechanisms of health and disease, and training young scientists. The FMI’s main areas of focus are neurobiology, quantitative biology and epigenetics and is affiliated with the University of Basel and the Novartis Institutes for BioMedical Research. Established in 1970, the FMI has been playing a leading role in biomedical research for half a century.

The Quantitative Biology Lab at FMI led by Prisca Liberali develops experimental and theoretical frameworks for the study of design principles of tissue organization during organoid development and regeneration. Her team combines high-content imaging platforms and light sheet-microscopy with single-cell modelling of stem cells in organoids.

The FMI’s work in the project comprises the characterization of colon organoids development with single-cell imaging, as a leader of the Work Package 3. In the Prisca Liberali laboratory, a complete workflow from organoid generation to image-based characterization of spatial organization of cell type has been established. This also included a cutting-edge image analysis platform that allows the interference of trajectories of organoid development.